DLEC1 Expression Is Modulated by Epigenetic Modifications in Hepatocelluar Carcinoma Cells: Role of HBx Genotypes
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DLEC1 Expression Is Modulated by Epigenetic Modifications in Hepatocelluar Carcinoma Cells: Role of HBx Genotypes
Deleted in Lung and Esophageal Cancer 1 (DLEC1) is a functional tumor suppressor gene (TSG). It has been found to be silenced in a variety of human cancers including hepatocellular carcinoma (HCC). The silencing of DLEC1 can be modulated by epigenetic modifications, such as DNA hypermethylation and histone hypoacetylation. In the case of HCC, hepatitis B virus X protein (HBx) has been implicate...
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1Division of Hepatology and Liver Research, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Groote Schuur Hospital, Western Cape, South Africa. 2Division of Rheumatology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Groote Schuur Hospital, Western Cape, South Africa. Received date: 14 Nov 2016; Accepted date: 12 Dec 2016; Published da...
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ژورنال
عنوان ژورنال: Cancers
سال: 2010
ISSN: 2072-6694
DOI: 10.3390/cancers2031689